Journal
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
Volume 7, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fcell.2019.00066
Keywords
THY-1; CD90; cancer; invasion; migration; ER stress; IRE1
Categories
Funding
- INSERM
- Institut National du Cancer (INCA)
- Region Bretagne
- Fondation pour la Recherche Medicale (FRM)
- EU H2020 [MSCA ITN-675448, MSCA RISE-734749]
- PROMISE, Bilateral GreeceChina Research Program of the Hellenic General Secretariat of Research and Technology [12CHN 204]
- Chinese Ministry of Science and Technology - Program Competitiveness and Entrepreneurship, Priority Health of the Peripheral Entrepreneurial Program of Attiki
- Plan Cancer
- Rennes Metropole
- la Ligue contre le Cancer (comite 35)
- la Ligue contre le Cancer (comite 56)
- la Ligue contre le Cancer (comite 37)
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CD90 is a membrane GPI-anchored protein with one Ig V-type superfamily domain that was initially described in mouse T cells. Besides the specific expression pattern and functions of CD90 that were described in normal tissues, i.e., neurons, fibroblasts and T cells, increasing evidences are currently highlighting the possible involvement of CD90 in cancer. This review first provides a brief overview on CD90 gene, mRNA and protein features and then describes the established links between CD90 and cancer. Finally, we report newly uncovered functional connections between CD90 and endoplasmic reticulum (ER) stress signaling and discuss their potential impact on cancer development.
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