Journal
GUT MICROBES
Volume 11, Issue 3, Pages 265-275Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/19490976.2019.1595300
Keywords
microbiome; alcoholic liver disease; ethanol-induced liver disease; Prevotella
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Funding
- NIAAA NIH HHS [R01 AA020703, U01 AA024726, U01 AA021856] Funding Source: Medline
- BLRD VA [I01 BX004594, I01 BX002213] Funding Source: Medline
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Alcohol-induced liver disease is closely related to translocation of bacterial products and bacteria from the intestine to the liver. However, it is not known whether bacterial translocation to the liver depends on certain intestinal microbiota changes that would predispose bacteria to translocate to the liver. In this study, we investigated the microbiota in the jejunum, ileum, cecum, feces and liver of mice subjected to chronic ethanol feeding using a Lieber DeCarli diet model of chronic ethanol feeding for 8 weeks. We demonstrate that chronic ethanol administration changes alpha diversity in the ileum and the liver and leads to compositional changes especially in the ileum. This is largely driven by an increase in gram-negative phyla - the source of endotoxins. Moreover, gram-negativePrevotellanot only increased in the mucus layer of the ileum but also in liver samples. These results suggest that bacterial translocation to the liver might be associated with microbiota changes in the distal gastrointestinal tract.
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