Journal
NATURE HUMAN BEHAVIOUR
Volume 3, Issue 9, Pages 950-961Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41562-019-0653-z
Keywords
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Funding
- NIHR Imperial College Health Care NHS Trust
- Imperial College London Biomedical Research Centre
- EU PhenoMeNal project (Horizon 2020) [654241]
- UK Dementia Research Institute - MRC
- Alzheimer's Society
- Alzheimer's Research UK
- Canadian Institutes of Health Research
- Universite Laval (Quebec City, Canada)
- Forschungs-und Forder-Stiftung INOVA, Vaduz, Liechtenstein
- NIH [R01-DK062370, U54 EB020403]
- ICIN-NHI [661395]
- Marie Sklodowska-Curie GF [661395]
- MRC
- ICIN-NHI
- National Natural Sciences Foundation of China [81873909]
- Shanghai Municipal Science and Technology Major Project [2018SHZDZX01]
- ZJLab
- NIHR Biomedical Research Centre at Imperial College Healthcare NHS Trust
- Imperial College London
- NIHR Health Protection Research Unit in Health Impact of Environmental Hazards [HPRU-2012-10141]
- Medical Research Council (MRC) UK [MR/L01341X/1]
- Health Data Research (HDR) UK
- Public Health England (PHE) Centre for Environment and Health UK [MR/L01341X/1]
- UK Dementia Research Institute (DRI) professorship
- UK DRI at Imperial College London - MRC
- European Union [LSHM-CT-2007-037286]
- Horizon 2020 [695313]
- ERANID [PR-ST-0416-10004]
- BRIDGET [MR/N027558/1]
- FP7 projects [602450, 603016]
- Innovative Medicine Initiative Project EU-AIMS [115300-2]
- Medical Research Council Grant 'c-VEDA' [MR/N000390/1]
- Swedish Research Council FORMAS
- Medical Research Council
- National Institute for Health Research (NIHR) Biomedical Research Centre at South London and Maudsley NHS Foundation Trust
- King's College London
- Bundesministeriumfur Bildung und Forschung (BMBF) [01GS08152, 01EV0711, eMED SysAlc01ZX1311A, 01EE1406A, 01EE1406B]
- Deutsche Forschungsgemeinschaft (DFG) [SM 80/7-2, SFB 940/2]
- Medical Research Foundation [MR/R00465X/1]
- Medical Research Council [MR/R00465X/1]
- Human Brain Project (HBP SGA 2)
- ANR [AF12-NEUR0008-01-WM2NA, ANR-12-SAMA-0004]
- Fondation de France
- Fondation pour la Recherche Medicale
- Mission Interministerielle de Lutte-contre-les-Drogues-et-les-Conduites-Addictives (MILDECA)
- Assistance-Publique-Hopitaux-de-Paris
- INSERM (interface grant), Paris Sud University IDEX 2012
- National Institutes of Health
- Science Foundation Ireland, USA [16/ERCD/3797, RO1 MH085772-01A1]
- Marie Curie Actions (MSCA) [661395] Funding Source: Marie Curie Actions (MSCA)
- Medical Research Council [MR/R00465X/1] Funding Source: researchfish
- Medical Research Foundation [MRF-058-0004-RG-DESRI] Funding Source: researchfish
- Science Foundation Ireland (SFI) [16/ERCD/3797] Funding Source: Science Foundation Ireland (SFI)
- MRC [UKDRI-5001, MR/L01341X/1, MR/R023484/1, G0700704, 1805065, MC_UU_00007/10, MR/R00465X/1, MR/R026505/1] Funding Source: UKRI
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Excessive alcohol consumption is one of the main causes of death and disability worldwide. Alcohol consumption is a heritable complex trait. Here we conducted a meta-analysis of genome-wide association studies of alcohol consumption (g d(-1)) from the UK Biobank, the Alcohol Genome-Wide Consortium and the Cohorts for Heart and Aging Research in Genomic Epidemiology Plus consortia, collecting data from 480,842 people of European descent to decipher the genetic architecture of alcohol intake. We identified 46 new common loci and investigated their potential functional importance using magnetic resonance imaging data and gene expression studies. We identify genetic pathways associated with alcohol consumption and suggest genetic mechanisms that are shared with neuropsychiatric disorders such as schizophrenia.
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