Journal
NATURE REVIEWS CHEMISTRY
Volume 3, Issue 7, Pages 426-441Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41570-019-0108-0
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Funding
- Spanish Government [MAT2015-64139-C4-1-R, RTI2018-100910-B-C41, AGL2015-70235-C2-2-R]
- Generalitat Valenciana [PROMETEO 2018/024]
- Spanish Ministry of Economy [FPU15/02707, FPU17/05454]
- la Caixa-Severo Ochoa PhD scholarship
- IRB
- Spanish Ministry of Economy (MINECO, SAF)
- European Research Council (ERC Advanced Grant)
- la Caixa Foundation
- MINECO/AEI/FEDER, UE
- Severo Ochoa Award of Excellence from the MINECO
- [SAF2017-84689-R]
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Senescence is a state of permanent cell cycle arrest. Cellular senescence can promote tissue remodelling but can negatively affect regenerative capacities of tissues and contribute to inflammation and the progression of cancer and ageing-related diseases. This Review highlights the chemical characteristics of senescence and how we can target senescent cells with small molecules to induce senescence in hyperproliferative tissues. Alternatively, these small molecules can also be administered to inhibit senescence or eliminate senescent cells as the basis of a promising strategy to treat ageing-related diseases. We also describe advances in detecting senescence in in vitro and in vivo models, such that we can evaluate response to treatments intended to induce or eliminate senescent cells.
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