Journal
BIOORGANIC & MEDICINAL CHEMISTRY
Volume 23, Issue 21, Pages 7035-7044Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2015.09.033
Keywords
Human cytomegalovirus; Varicella zoster virus; Antiviral; Non-nucleoside inhibitor; Uracil
Funding
- Russian Foundation for Basic Research [13-04-01391A]
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The need for novel therapeutic options to fight herpesvirus infections still persists. Herein we report the design, synthesis and antiviral evaluation of a new family of non-nucleoside antivirals, derived from 1-[omega-(4-bromophenoxy)alkyl]uracil derivatives - previously reported inhibitors of human cytomegalovirus (HCMV). Introduction of the N-(4-phenoxyphenyl)acetamide side chain at N-3 increased their potency and widened activity spectrum. The most active compounds in the series exhibit submicromolar activity against different viral strains of HCMV and varicella zoster virus (VZV) replication in HEL cell cultures. Inactivity against other DNA and RNA viruses, including herpes simplex virus 1/2, points to a novel mechanism of antiviral action. (C) 2015 Elsevier Ltd. All rights reserved.
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