Journal
OPEN FORUM INFECTIOUS DISEASES
Volume 6, Issue 7, Pages -Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/ofid/ofz288
Keywords
antibiotic resistance; antibiotic-resistant organism; fecal microbiota transplantation; hospital epidemiology; microbiome; multidrug-resistant organisms; resistome
Categories
Funding
- National Institute of Allergy And Infectious Diseases, National Institutes of Health [K23AI144036, UM1AI104681, 1K23AI137321]
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The intestinal tract is a recognized reservoir of antibiotic-resistant organisms (ARO), and a potential target for strategies to reduce ARO colonization. Microbiome therapies such as fecal microbiota transplantation (FMT) have been established as an effective treatment for recurrent Clostridioides difficile infection and may be an effective approach for reducing intestinal ARO colonization. In this article, we review the current published literature on the role of FMT for eradication of intestinal ARO colonization, review the potential benefit and limitations of the use of FMT in this setting, and outline a research agenda for the future study of FMT for intestinal ARO colonization.
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