Journal
PHARMACEUTICS
Volume 11, Issue 7, Pages -Publisher
MDPI
DOI: 10.3390/pharmaceutics11070301
Keywords
hyaluronic acid; cancer therapy; drug delivery; micelle; nanogel; silica nanoparticle; gold nanoparticle; metal organic framework
Categories
Funding
- Korea Foundation for the Advancement of Science & Creativity (KOFAC) - National Research Foundation of Korea [2017R1A2B4003617, 2018R1E1A2A02058946, 2016R1D1A1A02937456, 2016R1A5A1009405]
- National Research Foundation of Korea [2018R1E1A2A02058946, 2016R1D1A1A02937456] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Hyaluronic acid (HA) has been widely investigated in cancer therapy due to its excellent characteristics. HA, which is a linear anionic polymer, has biocompatibility, biodegradability, non-immunogenicity, non-inflammatory, and non-toxicity properties. Various HA nanomedicines (i.e., micelles, nanogels, and nanoparticles) can be prepared easily using assembly and modification of its functional groups such as carboxy, hydroxy and N-acetyl groups. Nanometer-sized HA nanomedicines can selectively deliver drugs or other molecules into tumor sites via their enhanced permeability and retention (EPR) effect. In addition, HA can interact with overexpressed receptors in cancer cells such as cluster determinant 44 (CD44) and receptor for HA-mediated motility (RHAMM) and be degraded by a family of enzymes called hyaluronidase (HAdase) to release drugs or molecules. By interaction with receptors or degradation by enzymes inside cancer cells, HA nanomedicines allow enhanced targeting cancer therapy. In this article, recent studies about HA nanomedicines in drug delivery systems, photothermal therapy, photodynamic therapy, diagnostics (because of the high biocompatibility), colloidal stability, and cancer targeting are reviewed for strategies using micelles, nanogels, and inorganic nanoparticles.
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