Journal
BIOORGANIC & MEDICINAL CHEMISTRY
Volume 23, Issue 20, Pages 6659-6665Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2015.09.003
Keywords
Aloe; Anthraquinone derivatives; Soluble epoxide hydrolase (sEH); Molecular simulation
Funding
- National Research Foundation of Korea (NRF) - Ministry of Education, Science and Technology, Republic of Korea [2009-0093815]
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Aloe is a short-stemmed succulent herb widely used in traditional medicine to treat various diseases and as raw material in cosmetics and heath foods. In this study, we isolated and identified two new anthraquinone derivatives, aloinoside C (6) and aloinoside D (7), together with six known compounds from an aqueous dissolved Aloe exudate. Their structures were identified by spectroscopic analysis. The inhibitory effects of the isolated compounds on soluble epoxide hydrolase (sEH) were evaluated. Compounds 1-8 inhibited sEH activity potently, with IC50 values ranging from 4.1 +/- 0.6 to 41.1 +/- 4.2 mu M. A kinetic analysis of compounds 1-8 revealed that the inhibitory actions of compounds 1, 6 and 8 were non-competitive, whereas those of compounds 2-5 and 7 were the mixed-type. Molecular docking increases our understanding of receptor-ligand binding of all compounds. These results demonstrate that compounds 1-8 from Aloe are potential sEH inhibitors. (c) 2015 Elsevier Ltd. All rights reserved.
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