Journal
ADVANCED MATERIALS TECHNOLOGIES
Volume 4, Issue 9, Pages -Publisher
WILEY
DOI: 10.1002/admt.201800533
Keywords
biosensors; molecularly imprinted polymers; photonic crystals; refractive index; waveguides
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Funding
- JSPS Research Fellowships for Young Scientist [16J05520]
- University of Tsukuba Nanotechnology Platform
- National Institute of Material Science Nanofabrication Platform
- Grants-in-Aid for Scientific Research [16J05520] Funding Source: KAKEN
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A compact photonic sensor using a perforated waveguide (PW) that functions as a bimodal interferometer (BiMI) is developed for affinity sensing. A 2D array of holes is formed on the bimodal region of the waveguide. The PW is designed to allow 1.31 mu m wavelength light to transmit, harnessing the strong optical intensity distribution inside the holes to enhance the sensitivity of the sensor. Numerical simulations show that the PW-BiMI outperforms a nonperforated BiMI in surface sensitivity by 7.6 times. A molecularly imprinted polymer for human serum albumin (HSA) is synthesized and coated on the PW-BiMI. The sensitivity and detection limit for HSA achieved using a 100 mu m long sensor are 154 nm mu m(-1) and 20.4 mu g mL(-1), respectively. Compared with a BiMI of equivalent length, the PW-BiMI sensor would have a 22 times larger surface sensitivity, and the detection limit would be decreased to 31%. The PW-BiMI sensor has potential for application in label-free biosensing with a small volume of solution.
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