Journal
CELLS
Volume 8, Issue 6, Pages -Publisher
MDPI
DOI: 10.3390/cells8060531
Keywords
trans-Golgi network; adaptor proteins; AP-1; AP-3; AP-4; GGAs; protein sorting; post-Golgi transport
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Funding
- National Health and Medical Research Council [APP1082600]
- University of Melbourne International Graduate Scholarships
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The trans-Golgi network (TGN) is responsible for selectively recruiting newly synthesized cargo into transport carriers for delivery to their appropriate destination. In addition, the TGN is responsible for receiving and recycling cargo from endosomes. The membrane organization of the TGN facilitates the sorting of cargoes into distinct populations of transport vesicles. There have been significant advances in defining the molecular mechanism involved in the recognition of membrane cargoes for recruitment into different populations of transport carriers. This machinery includes cargo adaptors of the adaptor protein (AP) complex family, and monomeric Golgi-localized gamma ear-containing Arf-binding protein (GGA) family, small G proteins, coat proteins, as well as accessory factors to promote budding and fission of transport vesicles. Here, we review this literature with a particular focus on the transport pathway(s) mediated by the individual cargo adaptors and the cargo motifs recognized by these adaptors. Defects in these cargo adaptors lead to a wide variety of diseases.
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