Journal
CELLS
Volume 8, Issue 6, Pages -Publisher
MDPI
DOI: 10.3390/cells8060569
Keywords
Mps one binder; Hippo pathway; protein kinase; signal transduction; phosphorylation; protein-protein interactions; structure biology; STK38; NDR; LATS; MST; STRIPAK
Categories
Funding
- Wellcome Trust [090090/Z/09/Z]
- BBSRC [BB/I021248/1]
- Worldwide Cancer Research [11-0634]
- UCL Cancer Research UK Centre
- National Institute for Health Research University College London Hospitals Biomedical Research Centre
- Research Council of the Republic of Turkey (TUBITAK) [119S007]
- BBSRC [BB/I021248/1] Funding Source: UKRI
- Wellcome Trust [090090/Z/09/Z] Funding Source: Wellcome Trust
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The family of MOBs (monopolar spindle-one-binder proteins) is highly conserved in the eukaryotic kingdom. MOBs represent globular scaffold proteins without any known enzymatic activities. They can act as signal transducers in essential intracellular pathways. MOBs have diverse cancer-associated cellular functions through regulatory interactions with members of the NDR/LATS kinase family. By forming additional complexes with serine/threonine protein kinases of the germinal centre kinase families, other enzymes and scaffolding factors, MOBs appear to be linked to an even broader disease spectrum. Here, we review our current understanding of this emerging protein family, with emphases on post-translational modifications, protein-protein interactions, and cellular processes that are possibly linked to cancer and other diseases. In particular, we summarise the roles of MOBs as core components of the Hippo tissue growth and regeneration pathway.
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