Related references
Note: Only part of the references are listed.Neuronal and Glial Differentiation of Human Neural Stem Cells Is Regulated by Amyloid Precursor Protein (APP) Levels
Raquel Coronel et al.
MOLECULAR NEUROBIOLOGY (2019)
Glutamate Receptor Trafficking and Protein Synthesis Mediate the Facilitation of LTP by Secreted Amyloid Precursor Protein-Alpha
Bruce G. Mockett et al.
JOURNAL OF NEUROSCIENCE (2019)
APP depletion alters selective pre- and post-synaptic proteins
Isak Martinsson et al.
MOLECULAR AND CELLULAR NEUROSCIENCE (2019)
Complex formation of APP with GABAB receptors links axonal trafficking to amyloidogenic processing
Margarita C. Dinamarca et al.
NATURE COMMUNICATIONS (2019)
A structural look at GABAA receptor mutations linked to epilepsy syndromes
Ciria C. Hernandez et al.
BRAIN RESEARCH (2019)
Amyloid precursor protein-mediated mitochondrial regulation and Alzheimer's disease
M. Isabel G. Lopez Sanchez et al.
BRITISH JOURNAL OF PHARMACOLOGY (2019)
Are antibodies directed against amyloid- (A) oligomers the last call for the A hypothesis of Alzheimer's disease?
Francesco Panza et al.
IMMUNOTHERAPY (2019)
Secreted amyloid-β precursor protein functions as a GABABR1a ligand to modulate synaptic transmission
Heather C. Rice et al.
SCIENCE (2019)
Role of Amyloid Precursor Protein (APP) and Its Derivatives in the Biology and Cell Fate Specification of Neural Stem Cells
Raquel Coronel et al.
MOLECULAR NEUROBIOLOGY (2018)
Lentivirus-mediated expression of human secreted amyloid precursor protein-alpha prevents development of memory and plasticity deficits in a mouse model of Alzheimer's disease
Valerie T. Y. Tan et al.
MOLECULAR BRAIN (2018)
Diversity of structure and function of GABAB receptors: a complexity of GABAB-mediated signaling
Miho Terunuma
PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES (2018)
Why do trials for Alzheimer's disease drugs keep failing? A discontinued drug perspective for 2010-2015
Dev Mehta et al.
EXPERT OPINION ON INVESTIGATIONAL DRUGS (2017)
The physiological role of the amyloid precursor protein as an adhesion molecule in the developing nervous system
Lucas J. Sosa et al.
JOURNAL OF NEUROCHEMISTRY (2017)
APLP1 Is a Synaptic Cell Adhesion Molecule, Supporting Maintenance of Dendritic Spines and Basal Synaptic Transmission
Sandra Schilling et al.
JOURNAL OF NEUROSCIENCE (2017)
Human Brain-Derived Aβ Oligomers Bind to Synapses and Disrupt Synaptic Activity in a Manner That Requires APP
Zemin Wang et al.
JOURNAL OF NEUROSCIENCE (2017)
Not just amyloid: physiological functions of the amyloid precursor protein family
Ulrike C. Mueller et al.
NATURE REVIEWS NEUROSCIENCE (2017)
Secreted amyloid precursor protein-alpha can restore novel object location memory and hippocampal LTP in aged rats
Monica Xiong et al.
NEUROBIOLOGY OF LEARNING AND MEMORY (2017)
LTP and memory impairment caused by extracellular Aβ and Tau oligomers is APP-dependent
Daniela Puzzo et al.
ELIFE (2017)
APP modulates KCC2 expression and function in hippocampal GABAergic inhibition
Ming Chen et al.
ELIFE (2017)
Cortical cells reveal APP as a new player in the regulation of GABAergic neurotransmission
Anna Doshina et al.
SCIENTIFIC REPORTS (2017)
The Amyloid Precursor Protein Is a Conserved Receptor for Slit to Mediate Axon Guidance
Baiping Wang et al.
ENEURO (2017)
Modular composition and dynamics of native GABAB receptors identified by high-resolution proteomics
Jochen Schwenk et al.
NATURE NEUROSCIENCE (2016)
The amyloid hypothesis of Alzheimer's disease at 25years
Dennis J. Selkoe et al.
EMBO MOLECULAR MEDICINE (2016)
A Greek Tragedy: The Growing Complexity of Alzheimer Amyloid Precursor Protein Proteolysis
Robert J. Andrew et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2016)
K+-Cl- co-transporter 2 (KCC2) - a membrane trafficking perspective
Bor Luen Tang
MOLECULAR MEMBRANE BIOLOGY (2016)
Leading Alzheimer's theory survives drug failure
Alison Abbott et al.
NATURE (2016)
Network abnormalities and interneuron dysfunction in Alzheimer disease
Jorge J. Palop et al.
NATURE REVIEWS NEUROSCIENCE (2016)
Role of GABAB receptors in learning and memory and neurological disorders
Chelcie F. Heaney et al.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (2016)
KCC2 rescues functional deficits in human neurons derived from patients with Rett syndrome
Xin Tang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)
Physiological role for amyloid precursor protein in adult experience-dependent plasticity
Sally A. Marik et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)
Synergic interaction between amyloid precursor protein and neural cell adhesion molecule promotes neurite outgrowth
Keping Chen et al.
ONCOTARGET (2016)
Impaired theta-gamma coupling in APP-deficient mice
Xiaomin Zhang et al.
SCIENTIFIC REPORTS (2016)
Role of Drosophila Amyloid Precursor Protein in Memory Formation
Thomas Preat et al.
FRONTIERS IN MOLECULAR NEUROSCIENCE (2016)
Extracellular association of APP and tau fibrils induces intracellular aggregate formation of tau
Muneaki Takahashi et al.
ACTA NEUROPATHOLOGICA (2015)
Cellular Functions of the Amyloid Precursor Protein from Development to Dementia
Rik van der Kant et al.
DEVELOPMENTAL CELL (2015)
APLP1 and APLP2, members of the APP family of proteins, behave similarly to APP in that they associate with NMDA receptors and enhance NMDA receptor surface expression
Sarah L. Cousins et al.
JOURNAL OF NEUROCHEMISTRY (2015)
η-Secretase processing of APP inhibits neuronal activity in the hippocampus
Michael Willem et al.
NATURE (2015)
Reversing excitatory GABAAR signaling restores synaptic plasticity and memory in a mouse model of Down syndrome
Gabriele Deidda et al.
NATURE MEDICINE (2015)
GABABreceptor deficiency causes failure of neuronal homeostasis in hippocampal networks
Irena Vertkin et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)
Delta-secretase cleaves amyloid precursor protein and regulates the pathogenesis in Alzheimer's disease
Zhentao Zhang et al.
NATURE COMMUNICATIONS (2015)
APP and APLP2 interact with the synaptic release machinery and facilitate transmitter release at hippocampal synapses
Tomas Fanutza et al.
ELIFE (2015)
Acute function of secreted amyloid precursor protein fragment APPs alpha in synaptic plasticity
Meike Hick et al.
ACTA NEUROPATHOLOGICA (2015)
The Amyloid Precursor Protein Controls Adult Hippocampal Neurogenesis through GABAergic Interneurons
Baiping Wang et al.
JOURNAL OF NEUROSCIENCE (2014)
Genetic Suppression of Transgenic APP Rescues Hypersynchronous Network Activity in a Mouse Model of Alzeimer's Disease
Heather A. Born et al.
JOURNAL OF NEUROSCIENCE (2014)
Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins
Benjamin G. Wilhelm et al.
SCIENCE (2014)
Shedding of APP limits its synaptogenic activity and cell adhesion properties
Ronny Stahl et al.
FRONTIERS IN CELLULAR NEUROSCIENCE (2014)
Holo-APP and G-protein-mediated signaling are required for sAPPα-induced activation of the Akt survival pathway
N. Milosch et al.
CELL DEATH & DISEASE (2014)
GABAB receptor trafficking and interacting proteins: Targets for the development of highly specific therapeutic strategies to treat neurological disorders?
Dietmar Benke
BIOCHEMICAL PHARMACOLOGY (2013)
Redundancy and divergence in the amyloid precursor protein family
S. Ali M. Shariati et al.
FEBS LETTERS (2013)
Amyloid precursor proteins are constituents of the presynaptic active zone
Melanie Lassek et al.
JOURNAL OF NEUROCHEMISTRY (2013)
Chloride extrusion enhancers as novel therapeutics for neurological diseases
Martin Gagnon et al.
NATURE MEDICINE (2013)
Analysis of the Overall Structure of the Multi-Domain Amyloid Precursor Protein (APP)
Ina Coburger et al.
PLOS ONE (2013)
Calsyntenin-1 mediates axonal transport of the amyloid precursor protein and regulates Aβ production
Alessio Vagnoni et al.
HUMAN MOLECULAR GENETICS (2012)
Amyloid Precursor Protein Regulates Netrin-1-mediated Commissural Axon Outgrowth
Nicolas Rama et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
sAPPa rescues deficits in amyloid precursor protein knockout mice following focal traumatic brain injury
Frances Corrigan et al.
JOURNAL OF NEUROCHEMISTRY (2012)
Amyloid precursor protein (APP) regulates synaptic structure and function
Sheue-Houy Tyan et al.
MOLECULAR AND CELLULAR NEUROSCIENCE (2012)
The GABA Excitatory/Inhibitory Shift in Brain Maturation and Neurological Disorders
Yehezkel Ben-Ari et al.
NEUROSCIENTIST (2012)
Sushi domains confer distinct trafficking profiles on GABAB receptors
Saad Hannan et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Physiological Functions of APP Family Proteins
Ulrike C. Mueller et al.
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2012)
Presenilins and γ-Secretase: Structure, Function, and Role in Alzheimer Disease
Bart De Strooper et al.
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2012)
The role of APP and APLP for synaptic transmission, plasticity, and network function: lessons from genetic mouse models
Martin Korte et al.
EXPERIMENTAL BRAIN RESEARCH (2012)
GABAB receptor modulation of synaptic function
Jason R. Chalifoux et al.
CURRENT OPINION IN NEUROBIOLOGY (2011)
NMDA receptor activity downregulates KCC2 resulting in depolarizing GABAA receptor-mediated currents
Henry H. C. Lee et al.
NATURE NEUROSCIENCE (2011)
How Inhibition Shapes Cortical Activity
Jeffry S. Isaacson et al.
NEURON (2011)
ADAM10 is the physiologically relevant, constitutive α-secretase of the amyloid precursor protein in primary neurons
Peer-Hendrik Kuhn et al.
EMBO JOURNAL (2010)
The Sushi Domains of GABAB Receptors Function as Axonal Targeting Signals
Barbara Biermann et al.
JOURNAL OF NEUROSCIENCE (2010)
Tyrosine phosphorylation regulates the membrane trafficking of the potassium chloride co-transporter KCC2
Henry H. C. Lee et al.
MOLECULAR AND CELLULAR NEUROSCIENCE (2010)
Down-regulation of the potassium-chloride cotransporter KCC2 contributes to spasticity after spinal cord injury
Pascale Boulenguez et al.
NATURE MEDICINE (2010)
GABAB Receptors Modulate NMDA Receptor Calcium Signals in Dendritic Spines
Jason R. Chalifoux et al.
NEURON (2010)
β-Amyloid Impairs AMPA Receptor Trafficking and Function by Reducing Ca2+/Calmodulin-dependent Protein Kinase II Synaptic Distribution
Zhenglin Gu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Amyloid precursor protein 695 associates with assembled NR2A-and NR2B-containing NMDA receptors to result in the enhancement of their cell surface delivery
Sarah L. Cousins et al.
JOURNAL OF NEUROCHEMISTRY (2009)
Amyloid Precursor Protein Regulates Cav1.2 L-type Calcium Channel Levels and Function to Influence GABAergic Short-Term Plasticity
Li Yang et al.
JOURNAL OF NEUROSCIENCE (2009)
Presynaptic and Postsynaptic Interaction of the Amyloid Precursor Protein Promotes Peripheral and Central Synaptogenesis
Zilai Wang et al.
JOURNAL OF NEUROSCIENCE (2009)
APP binds DR6 to trigger axon pruning and neuron death via distinct caspases
Anatoly Nikolaev et al.
NATURE (2009)
Amyloid-beta precursor protein mediates neuronal toxicity of amyloid beta through Go protein activation
Francisco Sola Vigo et al.
NEUROBIOLOGY OF AGING (2009)
Amyloid precursor protein knockout mice show age-dependent deficits in passive avoidance learning
Yann Senechal et al.
BEHAVIOURAL BRAIN RESEARCH (2008)
Role of upstream stimulating factors in the transcriptional regulation of the neuron-specific K-Cl cotransporter KCC2
Marika Markkanen et al.
BRAIN RESEARCH (2008)
GABAA receptor-mediated activation of L-type calcium channels induces neuronal excitation in surgically resected human hypothalamic hamartomas
Do Young Kim et al.
EPILEPSIA (2008)
Amyloid precursor protein cytoplasmic domain antagonizes reelin neurite outgrowth inhibition of hippocampal neurons
C. Hoareau et al.
NEUROBIOLOGY OF AGING (2008)
Endogenous secreted amyloid precursor protein-α regulates hippocampal NMDA receptor function, long-term potentiation and spatial memory
Chanel J. Taylor et al.
NEUROBIOLOGY OF DISEASE (2008)
The amyloid precursor protein intracellular domain (AICD) as modulator of gene expression, apoptosis, and cytoskeletal dynamics -: Relevance for Alzheimer's disease
Thorsten Mueller et al.
PROGRESS IN NEUROBIOLOGY (2008)
The secreted β-amyloid precursor protein ectodomain APPsα is sufficient to rescue the anatomical, behavioral, and electrophysiological abnormalities of APP-deficient mice
Sabine Ring et al.
JOURNAL OF NEUROSCIENCE (2007)
Early changes in KCC2 phosphorylation in response to neuronal stress result in functional downregulation
Hiroaki Wake et al.
JOURNAL OF NEUROSCIENCE (2007)
Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction
Weiping Qin et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Differential compartmentalization and distinct functions of GABAB receptor variants
Réjan Vigot et al.
NEURON (2006)
GABA regulates synaptic integration of newly generated neurons in the adult brain
SY Ge et al.
NATURE (2006)
Coordinated transport of phosphorylated amyloid-β precursor protein and c-Jun NH2-terminal kinase-interacting protein-1
Z Muresan et al.
JOURNAL OF CELL BIOLOGY (2005)
Beta-amyloid accumulation in APP mutant neurons reduces PSD-95 and GluR1 in synapses
CG Almeida et al.
NEUROBIOLOGY OF DISEASE (2005)
Homo- and heterodimerization of APP family members promotes intercellular adhesion
P Soba et al.
EMBO JOURNAL (2005)
Regulation of NMDA receptor trafficking by amyloid-β
EM Snyder et al.
NATURE NEUROSCIENCE (2005)
GABAB receptor antagonist SGS742 improves spatial memory and reduces protein binding to the cAMP response element (CRE) in the hippocampus
KA Helm et al.
NEUROPHARMACOLOGY (2005)
SGS742:: the first GABAB receptor antagonist in clinical trials
W Froestl et al.
BIOCHEMICAL PHARMACOLOGY (2004)
Cortical dysplasia resembling human type 2 lissencephaly in mice lacking all three APP family members
J Herms et al.
EMBO JOURNAL (2004)
Molecular structure and function of the glycine receptor chloride channel
JW Lynch
PHYSIOLOGICAL REVIEWS (2004)
Direct modulation of synaptic vesicle priming by GABAB receptor activation at a glutamatergic synapse
T Sakaba et al.
NATURE (2003)