Journal
CELLS
Volume 8, Issue 7, Pages -Publisher
MDPI
DOI: 10.3390/cells8070686
Keywords
cellular senescence; mitochondria; mitostasis; mitochondrial dynamics
Categories
Funding
- European Union [722729]
- Welfare Foundation for Social & Cultural Sciences (KIKPE), Greece
- Pentagon Biotechnology Ltd., UK
- DeepMed IO Ltd., UK
- NKUA-SARG [70/3/9816, 70/3/12128]
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Cellular senescence refers to a stress response aiming to preserve cellular and, therefore, organismal homeostasis. Importantly, deregulation of mitochondrial homeostatic mechanisms, manifested as impaired mitochondrial biogenesis, metabolism and dynamics, has emerged as a hallmark of cellular senescence. On the other hand, impaired mitostasis has been suggested to induce cellular senescence. This review aims to provide an overview of homeostatic mechanisms operating within mitochondria and a comprehensive insight into the interplay between cellular senescence and mitochondrial dysfunction.
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