Journal
CELLS
Volume 8, Issue 7, Pages -Publisher
MDPI
DOI: 10.3390/cells8070687
Keywords
nuclear envelope (NE); nuclear pore complex (NPC); nuclear lamina; cyclin dependent kinase (CDK); polo-like kinase (PLK); protein phosphatase; micronuclei (MN)
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Funding
- Wellcome Trust [210742/Z/18/Z]
- BBSRC [BB/K017632/1] Funding Source: UKRI
- Wellcome Trust [210742/Z/18/Z] Funding Source: Wellcome Trust
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The role of kinases in the regulation of cell cycle transitions is very well established, however, over the past decade, studies have identified the ever-growing importance of phosphatases in these processes. It is well-known that an intact or otherwise non-deformed nuclear envelope (NE) is essential for maintaining healthy cells and any deviation from this can result in pathological conditions. This review aims at assessing the current understanding of how phosphatases contribute to the remodelling of the nuclear envelope during its disassembling and reformation after cell division and how errors in this process may lead to the development of diseases.
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