Journal
CANCERS
Volume 11, Issue 6, Pages -Publisher
MDPI
DOI: 10.3390/cancers11060862
Keywords
cancer stem cells; DNA repair; radioresistance; 5Rs of radiation biology
Categories
Funding
- Deutsche Forschungsgemeinschaft (DFG) [273676790, 401326337, 416001651]
- Wilhelm Sander-Stiftung [2017.106.1]
- BMBF [02NUK032, 02NUK035B, 03Z1NN11]
- DLR Project Management Agency [01DK17047]
- DFG [BO1868-5]
- Hubertus Wald Stiftung
- Hamburger Krebsgesellschaft e.V.
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The current preclinical and clinical findings demonstrate that, in addition to the conventional clinical and pathological indicators that have a prognostic value in radiation oncology, the number of cancer stem cells (CSCs) and their inherent radioresistance are important parameters for local control after radiotherapy. In this review, we discuss the molecular mechanisms of CSC radioresistance attributable to DNA repair mechanisms and the development of CSC-targeted therapies for tumor radiosensitization. We also discuss the current challenges in preclinical and translational CSC research including the high inter- and intratumoral heterogeneity, plasticity of CSCs, and microenvironment-stimulated tumor cell reprogramming.
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