Journal
CANCERS
Volume 11, Issue 7, Pages -Publisher
MDPI
DOI: 10.3390/cancers11070956
Keywords
tumor angiogenesis; calcium channel; migration; TRP; prostate cancer
Categories
Funding
- Ministere de l'Education Nationale
- Institut National de la Sante et de la Recherche Medicale (INSERM)
- Institut National du Cancer [INCa-PLBIO14-213]
- Institut Universitaire de France (IUF)
- Fondation ARC pour la recherche sur le cancer [PJA 20141202010]
- Association pour la Recherche sur les Tumeurs de la Prostate (ARTP)
- University of Torino
- Compagnia di San Paolo [Torino_call2014_L2_130]
- SFFR [F 46.2/001]
- Universite Franco Italienne
- Institut Francais de Bioinformatique
- France Genomique
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Background: Transient receptor potential (TRP) channels control multiple processes involved in cancer progression by modulating cell proliferation, survival, invasion and intravasation, as well as, endothelial cell (EC) biology and tumor angiogenesis. Nonetheless, a complete TRP expression signature in tumor vessels, including in prostate cancer (PCa), is still lacking. Methods: In the present study, we profiled by qPCR the expression of all TRP channels in human prostate tumor-derived ECs (TECs) in comparison with TECs from breast and renal tumors. We further functionally characterized the role of the 'prostate-associated' channels in proliferation, sprout formation and elongation, directed motility guiding, as well as in vitro and in vivo morphogenesis and angiogenesis. Results: We identified three 'prostate-associated' genes whose expression is upregulated in prostate TECs: TRPV2 as a positive modulator of TEC proliferation, TRPC3 as an endothelial PCa cell attraction factor and TRPA1 as a critical TEC angiogenic factor in vitro and in vivo. Conclusions: We provide here the full TRP signature of PCa vascularization among which three play a profound effect on EC biology. These results contribute to explain the aggressive phenotype previously observed in PTEC and provide new putative therapeutic targets.
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