Journal
JOURNAL OF CLINICAL MEDICINE
Volume 8, Issue 7, Pages -Publisher
MDPI
DOI: 10.3390/jcm8071008
Keywords
advanced glycation end products; carboxymethyl-lysine; methylglyoxal-derived hydroimidazolone; insulin resistance; type 2 diabetes; cardiovascular disease
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Funding
- Monash Graduate Scholarship
- Monash International Postgraduate Scholarship
- National Heart Foundation Future Leader Fellowship [100864]
- Danish Ministry of Science, Technology, and Innovation
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Advanced glycation end products (AGEs) have been implicated in the pathophysiology of type 2 diabetes and cardiovascular disease. We aimed to determine the associations of urinary carboxymethyl-lysine (CML) and methylglyoxal-hydroimidazolone (MG-H1) levels with cardiometabolic parameters in metabolically healthy obese women. Anthropometric, glycemic, cardiovascular, and urinary AGE parameters were measured in 58 metabolically healthy obese women (age: 39.98 +/- 8.72 years; body mass index (BMI): 32.29 +/- 4.05 kg/m(2)). Urinary CML levels were positively associated with BMI (r = 0.29, p = 0.02). After adjustment for age and BMI, there was a trend for positive associations between urinary CML levels and fasting (p = 0.06) and 2 h insulin (p = 0.05) levels, and insulin resistance measured by homeostatic model assessment (HOMA-IR) (p = 0.06). Urinary MG-H1 levels were positively associated with systolic and diastolic blood pressure, pulse pressure, mean arterial pressure, and total and low-density lipoprotein cholesterol after adjustment for age, BMI, and HOMA-IR (all p ? 0.05). There were no associations between urinary CML levels and cardiovascular parameters, and between urinary MG-H1 levels and glycemic measurements. Our data support a role of urinary AGEs in the pathophysiology of insulin resistance and cardiovascular disease; however, future studies are highly warranted.
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