Journal
JOURNAL OF CLINICAL MEDICINE
Volume 8, Issue 7, Pages -Publisher
MDPI
DOI: 10.3390/jcm8071079
Keywords
Aggregatibacter actinomycetemcomitans; invasiveness; leukotoxin; cytolethal distending toxin; serum resistance; outer membrane vesicles
Categories
Funding
- TUA grants from the County Council of Vasterbotten, Sweden
- Insamlingsstiftelsen, Medical Faculty, Umea University
- Svenska Tandlakare-sallskapet
- Thureus Foundation
- Kempe Foundation
Ask authors/readers for more resources
Periodontitis is an infection-induced inflammatory disease that affects the tooth supporting tissues, i.e., bone and connective tissues. The initiation and progression of this disease depend on dysbiotic ecological changes in the oral microbiome, thereby affecting the severity of disease through multiple immune-inflammatory responses. Aggregatibacter actinomycetemcomitans is a facultative anaerobic Gram-negative bacterium associated with such cellular and molecular mechanisms associated with the pathogenesis of periodontitis. In the present review, we outline virulence mechanisms that help the bacterium to escape the host response. These properties include invasiveness, secretion of exotoxins, serum resistance, and release of outer membrane vesicles. Virulence properties of A. actinomycetemcomitans that can contribute to treatment resistance in the infected individuals and upon translocation to the circulation, also induce pathogenic mechanisms associated with several systemic diseases.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available