Journal
APPLIED NANOSCIENCE
Volume 10, Issue 8, Pages 3143-3148Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s13204-019-01098-y
Keywords
Nanoparticle; Titanium oxide; Theranostic; MRI; CT; Radiotherapy
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Nanoparticles (NPs) are useful for radiotherapy. Currently, efforts are underway globally for the development of novel titanium dioxide NPs (TiO2-NPs) that exhibit both contrast effects and anti-tumor effects. In this study, the image contrast properties of TiO2-NPs were evaluated using a clinical magnetic resonance imaging (MRI) system and a clinical computed tomography (CT) scanner, as the use of TiO2-NPs as an anti-cancer agent has been reported in several reports. An obvious difference in visualization was observed between the control and TiO2-NP samples onT(2)-weighted images. These results suggest that TiO(2)can potentially be used as a novel theranostic drug with radiosensitizing ability and radiological diagnostic ability, through modification of chemical groups on its surface, and as a component of drug delivery systems.
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