Journal
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
Volume 6, Issue 8, Pages 1552-1558Publisher
WILEY
DOI: 10.1002/acn3.50835
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Funding
- USA National Science Foundation [EPSCoR RII-2FEC OIA 1632891]
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The causal role of midline thalamus in the initiation and early organization of mesial temporal lobe seizures is studied. Three patients undergoing stereoelectroencephalography were enrolled for the placement of an additional depth electrode targeting the midline thalamus. The midline thalamus was recruited in all three patients at varying points of seizure initiation (0-13 sec) and propagation (9-60 sec). Stimulation of either thalamus or hippocampus induced similar habitual seizures. Seizure-induced in the hippocampus rapidly recruited the thalamus. Evoked potentials demonstrated stronger connectivity from the hippocampus to the thalamus than in the opposite direction. The midline thalamus can be within the seizure initiation and symptomatogenic circuits.
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