Journal
FRONTIERS IN CHEMISTRY
Volume 7, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fchem.2019.00471
Keywords
polydopamine; photosensitizers; drug delivery; photodynamic therapy; nanocarriers
Categories
Funding
- National Science Foundation of China [31700867, 51573039]
- Scientific Research Foundation of Huazhong University of Science and Technology [3004170130]
- Program for HUST Academic Frontier Youth Team [2018QYTD01]
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Photodynamic therapy (PDT) has emerged as a non-invasive modality for treating tumors while a photosensitizer (PS) plays an indispensable role in PDT. Nevertheless, free PSs are limited by their low light stability, rapid blood clearance, and poor water solubility. Constructing a nanocarrier delivering PSs is an appealing and potential way to solve these issues. As a melanin-like biopolymer, polydopamine (PDA) is widely utilized in biomedical applications (drug delivery, tissue engineering, and cancer therapy) for its prominent properties, including favorable biocompatibility, easy preparation, and versatile functionality. PDA-based nanocarriers are thus leveraged to overcome the inherent shortcomings of free PSs. In this Mini-Review, we will fi rstly present an overview on the recent developments of PDA nanocarriers delivering PSs. Then, we introduce three distinctive strategies developed to combine PSs with PDA nanocarriers. The advantages and disadvantages of each strategy will be discussed. Finally, the current challenges and future opportunities of PDA-based PS nanocarriers will also be addressed.
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