Journal
ACS CENTRAL SCIENCE
Volume 5, Issue 7, Pages 1289-1294Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acscentsci.9b00460
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Funding
- Center for Genetically Encoded Materials, an NSF Center for Chemical Innovation [NSF CHE-1740549]
- Agilent Technologies
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Here, we report that wild type Escherichia coli ribosomes accept and elongate precharged initiator tRNAs acylated with multiple benzoic acids, including aramid precursors, as well as malonyl (1,3-dicarbonyl) substrates to generate a diverse set of aramid-peptide and polyketide-peptide hybrid molecules. This work expands the scope of ribozyme-and ribosome-catalyzed chemical transformations, provides a starting point for in vivo translation engineering efforts, and offers an alternative strategy for the biosynthesis of polyketide-peptide natural products.
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