Journal
FRONTIERS IN IMMUNOLOGY
Volume 10, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2019.01166
Keywords
galectins; pregnancy; placentation; glycans; preeclampsia
Categories
Funding
- German Research Foundation (DFG)
- Charite-Universitatsmedizin Berlin
- DFG [BL1115/2-1, BL1115/3-1, BL1115/4-1]
- Ministerio de Ciencia y Tecnologia (MINCYT, Argentina) [01DN16022]
- Bundesministerium fur Bildung und Forschung-Deutschen Zentrum fur Luft und Raumfahrt (BMBF-DLR, Germany) [01DN16022]
- National Institutes of Health [R01GM070589, R21AI120918]
- National Science Foundation [IOS-1656720, IOS-1050518]
- Collaborative Health Initiative Research Program at USUHS [401738]
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Galectins are a phylogenetically conserved family of soluble beta-galactoside binding proteins, consisting of 15 different types, each with a specific function. Galectins contribute to placentation by regulating trophoblast development, migration, and invasion during early pregnancy. In addition, galectins are critical players regulating maternal immune tolerance to the embedded embryo. Recently, the role of galectins in angiogenesis during decidualization and in placenta formation has gained attention. Altered expression of galectins is associated with abnormal pregnancies and infertility. This review focuses on the role of galectins in pregnancy-associated processes and discusses the relevance of galectin-glycan interactions as potential therapeutic targets in pregnancy disorders.
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