Journal
FRONTIERS IN IMMUNOLOGY
Volume 10, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2019.00772
Keywords
lupus (SLE); innate immunity; dendritic cells; macrophage-cell; innate lymphoid cell
Categories
Funding
- Redes Internacionales [REDI170651]
- Proyecto interno Universidad Autonoma de Chile [DIUA 134-2018]
- National Multiple Sclerosis Society [PP-1805-30965]
- Proyecto Genera-Autonoma [UA 17-04]
- FONDECYT de Inicio, CONICYT [11160592]
- Proyecto Vicerrectoria de Investigacion, Pontificia Universidad Catolica de Chile Puente [P1802]
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Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by the presence of autoantibodies against nuclear antigens, immune complex deposition, and tissue damage in the kidneys, skin, heart and lung. Because of the pathogenic role of antinuclear antibodies and autoreactive T cells in SLE, extensive efforts have been made to demonstrate how B cells act as antibody-producing or as antigen-presenting cells that can prime autoreactive T cell activation. With the discovery of new innate immune cells and inflammatory mediators, innate immunity is emerging as a key player in disease pathologies. Recent work over the last decade has highlighted the importance of innate immune cells and molecules in promoting and potentiating SLE. In this review, we discuss recent evidence of the involvement of different innate immune cells and pathways in the pathogenesis of SLE. We also discuss new therapeutics targets directed against innate immune components as potential novel therapies in SLE.
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