Journal
FRONTIERS IN IMMUNOLOGY
Volume 10, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2019.01096
Keywords
T(H)1; T(FH)1; IFN-gamma; follicular T helper cells; B cells; malaria; humoral immunity
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Funding
- Bill and Melinda Gates Foundation [OPP1091355, OPP1080385]
- Bill and Melinda Gates Foundation [OPP1080385, OPP1091355] Funding Source: Bill and Melinda Gates Foundation
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Humoral immunity is a critical effector arm for protection against malaria but develops only slowly after repeated infections. T cell-mediated regulatory dynamics affect the development of antibody responses to Plasmodium parasites. Here, we hypothesize that T follicular helper cell (T-FH) polarization generated by repeated Plasmodium asexual blood-stage infections delays the onset of protective humoral responses. IFN-gamma production promotes polarization toward T(FH)1 and increased generation of regulatory follicular helper cells (T-FR). Delineating the mechanisms that drive T(H)1 polarization will provide clues for appropriate induction of lasting, protective immunity against malaria.
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