Journal
FRONTIERS IN IMMUNOLOGY
Volume 10, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2019.00922
Keywords
N6-methyladenosine; binding proteins; mechanisms; immunoregulation; cellular functions
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Funding
- National Key R&D Program of China [2016YFC1305102]
- National Natural Science Foundation of China [81671561]
- 1000 Young Talents Plan Program of China
- Fudan Children's Hospital
- Fudan University
- International Joint Laboratory Program of National Children's Medical Center [EK1125180109]
- Shanghai Municipal Planning Commission of Science and Research Fund [201740065]
- Shanghai Pujiang Program [16PJ1401600]
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Over 100 types of cellular RNA modifications have been identified in both coding and a variety of non-coding RNAs. N6-methyladenosine (m6A) is the most prevalent and abundant post-transcriptional RNA modification on eukaryote mRNA, and its biological functions are mediated by special binding proteins (i.e., methyltransferases, demethylases, and effectors) that recognize this modification. The presence of m6A on transcripts contributes to diverse fundamental cellular functions, such as pre-mRNA splicing, nuclear transport, stability, translation, and microRNA biogenesis, implying an association with numerous human diseases. This review principally summarizes recent progress in the study of m6A methylation mechanisms and relevant roles they play in immunoregulation.
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