Journal
ANNUAL REVIEW OF VIROLOGY, VOL 6, 2019
Volume 6, Issue -, Pages 275-296Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev-virology-092818-015716
Keywords
human papillomavirus; Epstein-Barr virus; Kaposi's sarcoma-associated herpesvirus; DNA replication; partitioning; persistent infection
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Funding
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [ZIAAI000713] Funding Source: NIH RePORTER
- Intramural NIH HHS [Z01 AI001073] Funding Source: Medline
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Persistent viral infections require a host cell reservoir that maintains functional copies of the viral genome. To this end, several DNA viruses maintain their genomes as extrachromosomal DNA minichromosomes in actively dividing cells. These viruses typically encode a viral protein that binds specifically to viral DNA genomes and tethers them to host mitotic chromosomes, thus enabling the viral genomes to hitchhike or piggyback into daughter cells. Viruses that use this tethering mechanism include papillomaviruses and the gammaherpesviruses Epstein-Barr virus and Kaposi's sarcoma-associated herpesvirus. This review describes the advantages and consequences of persistent extrachromosomal viral genome replication.
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