Journal
ADVANCED SCIENCE
Volume 6, Issue 16, Pages -Publisher
WILEY
DOI: 10.1002/advs.201900925
Keywords
flexible sensors; in situ detection; surface-enhanced Raman scattering; swab-sampling approach; tunable surface plasmon resonance
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Funding
- RIE2020 Advanced Manufacturing and Engineering (AME) Individual Research Grant (IRG) [A1883c0010]
- A*STAR
- SERC 2014 Public Sector Research Funding (PSF) Grant (SERC Project) [1421200080]
- National Natural Science Foundation of China [61605162]
- Natural Science Foundation of Fujian Province of China [2017J05106]
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Surface-enhanced Raman scattering (SERS) spectroscopy provides a noninvasive and highly sensitive route for fingerprint and label-free detection of a wide range of molecules. Recently, flexible SERS has attracted increasingly tremendous research interest due to its unique advantages compared to rigid substrate-based SERS. Here, the latest advances in flexible substrate-based SERS diagnostic devices are investigated in-depth. First, the intriguing prospect of point-of-care diagnostics is briefly described, followed by an introduction to the cutting-edge SERS technique. Then, the focus is moved from conventional rigid substrate-based SERS to the emerging flexible SERS technique. The main part of this report highlights the recent three categories of flexible SERS substrates, including actively tunable SERS, swab-sampling strategy, and the in situ SERS detection approach. Furthermore, other promising means of flexible SERS are also introduced. The flexible SERS substrates with low-cost, batch-fabrication, and easy-to-operate characteristics can be integrated into portable Raman spectroscopes for point-of-care diagnostics, which are conceivable to penetrate global markets and households as next-generation wearable sensors in the near future.
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