Journal
NANOMATERIALS
Volume 9, Issue 7, Pages -Publisher
MDPI
DOI: 10.3390/nano9070997
Keywords
lignin; beta-cyclodextrin; hollow nanoparticles; hydroxycamptothecin; sustained release
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Funding
- National Natural Science Foundation of China [31770610]
- National Non-Profit Special Fund for Fundamental Research from the Chinese Academy of Forestry [CAFYBB2017ZX003]
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Due to its abundance, degradability, and low toxicity, lignin is a promising raw material for the preparation of nanomaterials. However, efficient encapsulation using lignin-nanomaterial for sustained-release medications remains a challenge. This study involves grafting beta-cyclodextrin (beta-CD), with a hollow toroidal structure, onto the enzymatic-hydrolysis lignin (EHL) to form CD-EHL. The modified lignin was next used to prepare hollow nanoparticles (LHNPs) via self-assembly to encapsulate the antitumor drug hydroxycamptothecin (HCPT). The results indicated that beta-CD improved the network structure of modified lignin molecules. Moreover, LHNPs that self-assembled using CD-EHL had an increased specific surface area and greater porosity, and exhibited a spherical hollow structure and stability in phosphate-buffered saline. The drug loading and encapsulation efficiency of HCPT were 70.6 +/- 9% and 22.02 +/- 2%, respectively. An in vitro study showed that lignin-based nanoparticles have low toxicity, and the modified LHNPs demonstrated a good sustained-release capability. This study broadened the potential application of lignin as a renewable biomass material.
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