Journal
LANCET DIABETES & ENDOCRINOLOGY
Volume 7, Issue 9, Pages 673-683Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/S2213-8587(19)30151-2
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Funding
- National Institute on Aging (NIA), National Institute of Health [U01AG022132, U01AG020478, U01AG020487, U01AG020480]
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institute of Health [U01AG022132, U01AG020478, U01AG020487, U01AG020480]
- NIA/NIH [AG20487]
- NIH General Clinical Research Center [RR00036]
- Diabetes Research Training Center [DK20579]
- NIH Clinical Nutrition Research Unit [DK56341]
- NIH [AG00078]
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Background For several cardiometabolic risk factors, values considered within normal range are associated with an increased risk of cardiovascular morbidity and mortality: We aimed to investigate the short-term and long-term effects of calorie restriction with adequate nutrition on these risk factors in healthy, lean, or slightly overweight young and middle-aged individuals. Methods CALERIE was a phase 2, multicentre, randomised controlled trial in young and middle-aged (21-50 years), healthy non-obese (BMI 22-0-27.9 kg/m(2)) men and women done in three clinical centres in the USA. Participants were randomly assigned (2:1) to a 25% calorie restriction diet or an ad libitum control diet. Exploratory cardiometabolic risk factor responses to a prescribed 25% calorie restriction diet for 2 years were evaluated (systolic, diastolic, and mean blood pressure; plasma lipids; high-sensitivity C-reactive protein; metabolic syndrome score; and glucose homoeostasis measures of fasting insulin, glucose, insulin resistance, and 2-h glucose, area-under-the curve for glucose, and insulin from an oral glucose tolerance test) analysed in the intention-to-treat population. This study is registered with ClinicalTrials.gov, number NCT00427193. Findings From May 8,2007, to Feb 26,2010, of 238 participants that were assessed, 218 were randomly assigned to and started a 25% calorie restriction diet (n=143, 66%) or an ad libitum control diet (n=75,34%). Individuals in the calorie restriction group achieved a mean reduction in calorie intake of 11.9% (SE 0.7; from 2467 kcal to 2170 kcal) versus 0.8% (1.0) in the control group, and a sustained mean weight reduction of 7.5 kg (SE 0.4) versus an increase of 0.1 kg (0.5) in the control group, of which 71% (mean change in fat mass 5.3 kg [SE 0.3] divided by mean change in weight 7.5 kg [0.4]) was fat mass loss. Calorie restriction caused a persistent and significant reduction from baseline to 2 years of all measured conventional cardiometabolic risk factors, including change scores for LDL-cholesterol (p<0.0001), total cholesterol to HDL-cholesterol ratio (p<0.0001), and systolic (p<0.0011) and diastolic (p<0.0001) blood pressure. In addition, calorie restriction resulted in a significant improvement at 2 years in C-reactive protein (p=0 . 012), insulin sensitivity index (p<0.0001), and metabolic syndrome score (p<0 . 0001) relative to control. A sensitivity analysis revealed the responses to be robust after controlling for relative weight loss changes. Interpretation 2 years of moderate calorie restriction significantly reduced multiple cardiometabolic risk factors in young, non-obese adults. These findings suggest the potential for a substantial advantage for cardiovascular health of practicing moderate calorie restriction in young and middle-aged healthy individuals, and they offer promise for pronounced long-term population health benefits. Copyright (C) 2019 Elsevier Ltd. All rights reserved.
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