Journal
ARCHIVES OF PHARMACAL RESEARCH
Volume 39, Issue 7, Pages 1006-1012Publisher
PHARMACEUTICAL SOC KOREA
DOI: 10.1007/s12272-016-0783-z
Keywords
Inulae flos; Britanin; Airway hyperresponsiveness (AHR); Eosinophils; Bronchoalveolar lavage fluids (BALF)
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Funding
- Ministry of Health & Welfare, Republic of Korea [HI13C0538]
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We previously demonstrated the alleviation of ovalbumin (OVA)-induced airway inflammation by Inulae flos. In the present study, the effects of britanin, a sesquiterpene compound isolated from Inulae flos, were evaluated in an in vivo animal model for anti-asthma activity through observation of airway hyperresponsiveness (AHR), eosinophil recruitment, Th2 cytokine and IgE levels, and lung histopathology. Britanin administration effectively reduced AHR induced by aerosolized methacholine, airway eosinophilia, Th2 cytokines in bronchoalveolar lavage fluids and the supernatant of cultured splenocytes compared with OVA-induced mice. Histological studies showed that increased inflammatory cell infiltration and mucus secretion were reduced by britanin administration. Thus, britanin may have therapeutic potential for treating allergic asthma.
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