NMR assignments of the C-terminal domain of human galectin-8

Galectins recognize beta-galectosides to promote a variety of cellular functions. Despite their sequence variations, all galectins share the same carbohydrate recognition domains (CRD) and their modes of ligand recognition at a structural level are essentially identical. Human galectin 8 plays an important role in numerous cancer and immune responses. It consists of two CRDs that are connected via a flexible linker. The substrate affinities and specificities of the N- and C-terminal domains are quite different. In order to investigate the structural basis of their substrate specificities, we complete the NMR H-1, C-13, and N-15 chemical shift assignments of C-terminal domain of human galectin-8 (hG8C).