Journal
JOURNAL OF THE AMERICAN HEART ASSOCIATION
Volume 8, Issue 11, Pages -Publisher
WILEY
DOI: 10.1161/JAHA.118.011319
Keywords
coronary aneurysm; echocardiography; Kawasaki disease; risk score
Categories
Funding
- Mentored Clinical and Population Research Award from the American Heart Association [16MCPRP30250004]
- McCance Family Foundation
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Background-Accurate prediction of coronary artery aneurysms (CAAs) in patients with Kawasaki disease remains challenging in North American cohorts. We sought to develop and validate a risk model for CAA prediction. Methods and Results-A binary outcome of CAA was defined as left anterior descending or right coronary artery Z score >= 2.5 at 2 to 8 weeks after fever onset in a development cohort (n =903) and a validation cohort (n =185) of patients with Kawasaki disease. Associations of baseline clinical, laboratory, and echocardiographic variables with later CAA were assessed in the development cohort using logistic regression. Discrimination (c statistic) and calibration (Hosmer-Lemeshow) of the final model were evaluated. A practical risk score assigning points to each variable in the final model was created based on model coefficients from the development cohort. Predictors of CAAs at 2 to 8 weeks were baseline Z score of left anterior descending or right coronary artery >= 2.0, age <6 months, Asian race, and C-reactive protein >= 13 mg/dL (c=0.82 in the development cohort, c=0.93 in the validation cohort). The CAA risk score assigned 2 points for baseline Z score of left anterior descending or right coronary artery >= 2.0 and 1 point for each of the other variables, with creation of low- (0-1), moderate- (2), and high- (3-5) risk groups. The odds of CAAs were 16-fold greater in the high- versus the low-risk groups in the development cohort (odds ratio, 16.4; 95% CI, 9.71-27.7 [P<0.001]), and >40-fold greater in the validation cohort (odds ratio, 44.0; 95% CI, 10.8-180 [P<0.001]). Conclusions-Our risk model for CAA in Kawasaki disease consisting of baseline demographic, laboratory, and echocardiographic variables had excellent predictive utility and should undergo prospective testing.
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