Journal
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
Volume 7, Issue 15, Pages 13286-13293Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acssuschemeng.9b02520
Keywords
Alkynes; Bismuth; Flow chemistry; Hydration; Ketones
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Funding
- Hungarian Research Foundation (OTKA) [K 115731]
- Ministry of Human Capacities, Hungary [20391-3/2018/FEKUSTRAT]
- Premium Post Doctorate Research Program of the Hungarian Academy of Sciences
- [GINOP-2.3.2-15-2016-00038]
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Environmentally benign synthesis of methyl ketones is demonstrated via unprecedented bismuth(III)-catalyzed activation and Markovnikov-type hydration of terminal acetylenes. Besides a batch process operating under reasonably mild conditions, a chemically intensified high-temperature continuous-flow methodology has also been developed using a coil reactor. The preparative capabilities of the flow process were demonstrated with multigram-scale alkyne hydrations. The methods presented rely on readily available bismuth(III) salts as green catalysts and exhibit less environmental concerns than earlier methods.
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