Reviewing evidence of the clinical effectiveness of commercially available antivenoms in sub-Saharan Africa identifies the need for a multi-centre, multi-antivenom clinical trial

Background Snakebite envenoming kills more than more than 20,000 people in Sub-Saharan Africa every year. Poorly regulated markets have been inundated with low-price, low-quality antivenoms. This review aimed to systematically collect and analyse the clinical data on all antivenom products now available in markets of sub-Saharan Africa. Methodology/Principal findings Our market analysis identified 12 polyspecific and 4 monospecific antivenom products in African markets. Our search strategy was first based on a systematic search of publication databases, followed by manual searches and discussions with experts. All types of data, including programmatic data, were eligible. All types of publications were eligible, including grey literature. Cohorts of less than 10 patients were excluded. 26 publications met the inclusion criteria. Many publications had to be excluded because clinical outcomes were not clearly linked to a specific product. Our narrative summaries present product-specific clinical data in terms of safety and effectiveness against the different species and envenoming syndromes. Three products (EchiTabPlus, EchiTabG, SAIMR-Echis-monovalent) were found to have been tested in robust clinical studies and found effective against envenoming caused by the West African carpet viper (Echis ocellatus). Four products (Inoserp-Panafricain, Fav-Afrique, SAIMR-Polyvalent, Antivipmyn-Africa) were found to have been evaluated only in observational single-arm studies, with varying results. For nine other products, there are either no data in the public domain, or only negative data suggesting a lack of effectiveness. Conclusions/Significance Clinical data vary among the different antivenom products currently in African markets. Some products are available commercially although they have been found to lack effectiveness. The World Health Organization should strengthen its capacity to assess antivenom products, support antivenom manufacturers, and assist African countries and international aid organizations in selecting appropriate quality antivenoms. Author summary Snakebite envenomation represents one of the most neglected tropical medical conditions worldwide. Despite high levels of morbidity and mortality associated with snakebite, its neglected nature has compromised the availability and evaluation of antivenom treatment. This review was initiated by Medecins Sans Frontieres' / Doctors Without Borders (MSF) Access Campaign, as the existing antivenom access crisis in sub-Saharan Africa was deepening. This study sought to review the clinical data pertaining to each antivenom product currently available for use in sub-Saharan Africa. 16 different antivenoms were identified. A total of 26 studies met the inclusion criteria. Given the heterogeneity of study methodology and quality, data for individual antivenoms are presented in the form of a narrative analysis. Only two studies reported clinical data collected from randomized controlled trials. Consistent monitoring of the side effects of antivenom treatment was lacking. The absence of good quality data for the majority of antivenoms in sub-Saharan Africa is a major concern. Further robust data collection is required, while urgent investments are needed at the global level to ensure a sustained production of safe and effective antivenom treatment, and its affordable access across sub-Saharan Africa.