Journal
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
Volume 13, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fnbeh.2019.00126
Keywords
Bifidobacterium adolescentis; antidepressant; chronic restraint stress; gut microbiota; inflammation
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Funding
- National Natural Science Foundation of China [31760297]
- Applied Basic Research Foundation of Yunnan Province [2017FE467-160]
- Yunnan Provincial Department of Education Foundation [601160911]
- key project of Applied Bascic Research Foundation of Yunnan Province (Study on the antidepressant active components and mechanism of rosemary)
- cultivation object of Yunnan innovation team (Kunming Medical University innovation team for the discovery and utilization of the active ingredients of toxic medicinal plants)
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Stress disturbs the balance of the gut microbiota and stimulates inflammationto-brain mechanisms. Moreover, stress leads to anxiety and depressive disorders. Bifidobacterium adolescentis displays distinct anti-inflammatory effects. However, no report has focused on the anxiolytic and antidepressant effects of B. adolescentis related to the gut microbiome and the inflammation on chronic restraint stress (CRS) in mice. We found that pretreatment with B. adolescentis increased the time spent in the center of the open field apparatus, increased the percentage of entries into the open arms of the elevated plus-maze (EPM) and the percentage of time spent in the open arms of the EPM, and decreased the immobility duration in the tail suspension test as well as the forced swimming test (FST). Moreover, B. adolescentis increased the sequence proportion of Lactobacillus and reduced the sequence proportion of Bacteroides in feces. Furthermore, B. adolescentis markedly reduced the protein expression of interleukin-1 beta (IL-1 beta), tumor necrosis factor a (TNF-alpha), p-nuclear factor-kappa B (NF-kappa B) p65 and Iba1 and elevated brain derived neurotrophic factor (BDNF) expression in the hippocampus. We conclude that the anxiolytic and antidepressant effects of B. adolescentis are related to reducing inflammatory cytokines and rebalancing the gut microbiota.
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