Journal
ADVANCED HEALTHCARE MATERIALS
Volume 8, Issue 18, Pages -Publisher
WILEY
DOI: 10.1002/adhm.201900501
Keywords
amorphous calcium carbonate; apoptosis; calcium overload; curcumin; mitochondria
Funding
- National Nature Science Foundation of China [81573366, 81773644, 81773648, 81473144]
- Zhejiang Provincial Public and Application Research Program [2016C33131]
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Calcium (Ca2+) hemeostasis is crucial for the normal function of cellular biochemistry. The abnormal frequency of Ca2+ signaling in cancer cells makes them more vulnerable to Ca2+ modulation than normal cells. Here in this study, a novel cancer-specific therapy by artificially triggering Ca2+ overload in cancer cells is proposed. The feasibility of this therapy is illustrated by successful coupling of selective extrusion (Ca2+) inhibition effect of Curcumin (Cur) and the effective Ca2+ generating capability of amorphous calcium carbonate (ACC) into a facilely prepared water responsive phospholipid (PL)-ACC hybrid platform (PL/ACC-Cur). The obtained results demonstrate that PL/ACC-Cur can specifically boost the intracellular Ca2+ concentration to cause Ca2+ overload and to trigger mitochondria-related apoptosis in MCF-7 cells while sparing normal hepatocyte (L02), which might be a promising approach for effective cancer therapy.
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