Journal
SCIENTIFIC REPORTS
Volume 9, Issue -, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41598-019-45858-w
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Funding
- Dutch Province of Limburg
- Novartis Pharma
- European Regional Development Fund via OP-Zuid
- Province of Limburg
- Dutch Ministry of Economic Affairs [31 O.041]
- Stichting De Weijerhorst (Maastricht, the Netherlands)
- Pearl String Initiative Diabetes (Amsterdam, the Netherlands)
- CARIM School for Cardiovascular Diseases (Maastricht, the Netherlands)
- Stichting Annadal (Maastricht, the Netherlands)
- Janssen-Cilag B.V. (Tilburg, the Netherlands)
- Novo Nordisk Farma B.V. (Alphen aan den Rijn, the Netherlands)
- Sanofi-Aventis Netherlands B.V. (Gouda, the Netherlands)
- Health Foundation Limburg (Maastricht, the Netherlands)
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The Muscle Insulin Sensitivity Index (MISI) has been developed to estimate muscle-specific insulin sensitivity based on oral glucose tolerance test (OGTT) data. To date, the score has been implemented with considerable variation in literature and initial positive evaluations were not reproduced in subsequent studies. In this study, we investigate the computation of MISI on oral OGTT data with differing sampling schedules and aim to standardise and improve its calculation. Seven time point OGTT data for 2631 individuals from the Maastricht Study and seven time point OGTT data combined with a hyperinsulinemic-euglycaemic clamp for 71 individuals from the PRESERVE Study were used to evaluate the performance of MISI. MISI was computed on subsets of OGTT data representing four and five time point sampling schedules to determine minimal requirements for accurate computation of the score. A modified MISI computed on cubic splines of the measured data, resulting in improved identification of glucose peak and nadir, was compared with the original method yielding an increased correlation (rho = 0.576) with the clamp measurement of peripheral insulin sensitivity as compared to the original method (rho = 0.513). Finally, a standalone MISI calculator was developed allowing for a standardised method of calculation using both the original and improved methods.
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