Journal
SCIENTIFIC REPORTS
Volume 9, Issue -, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41598-019-46630-w
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Funding
- U.K. EPSRC [EP/J018171/1, EP/J500094/1, EP/N028694/1]
- EC [654148, 312453, 653782, 730871]
- Extreme Light Infrastructure (ELI) European Project
- National Physical Laboratory Director's Science and Engineering Fund
- National Physical Laboratory National Measurement System
- EPSRC [EP/N028694/1, EP/J018171/1] Funding Source: UKRI
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The increased inertia of very high-energy electrons (VHEEs) due to relativistic effects reduces scattering and enables irradiation of deep-seated tumours. However, entrance and exit doses are high for collimated or diverging beams. Here, we perform a study based on Monte Carlo simulations of focused VHEE beams in a water phantom, showing that dose can be concentrated into a small, well-defined volumetric element, which can be shaped or scanned to treat deep-seated tumours. The dose to surrounding tissue is distributed over a larger volume, which reduces peak surface and exit doses for a single beam by more than one order of magnitude compared with a collimated beam.
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