Journal
SCIENTIFIC REPORTS
Volume 9, Issue -, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41598-019-42401-9
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Funding
- Erasmus MC, University Medical Centre, Rotterdam - Erasmus MC Medical research advisory committee (Mrace) [343564]
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Tissue-resident memory T (T-RM) cells are characterized by their surface expression of CD69 and can be subdivided in CD103+ and CD103-T-RM cells. The origin and functional characteristics of T-RM cells in the renal allograft are largely unknown. To determine these features we studied T-RM cells in transplant nephrectomies. T-RM cells with a CD103+ and CD103-phenotype were present in all samples (n = 13) and were mainly CD8+ T cells. Of note, donor-derived T-RM cells were only detectable in renal allografts that failed in the first month after transplantation. Grafts, which failed later, mainly contained recipient derived T-RM cells. The gene expression profiles of the recipient derived CD8+ T-RM cells were studied in more detail and showed a previously described signature of tissue residence within both CD103+ and CD103-T-RM cells. All CD8+ T-RM cells had strong effector abilities through the production of IFN gamma and TNF alpha, and harboured high levels of intracellular granzyme B and low levels of perforin. In conclusion, our results demonstrate that donor and recipient T-RM cells reside in the rejected renal allograft. Over time, the donor-derived T-RM cells are replaced by recipient T-RM cells which have features that enables these cells to aggressively respond to the allograft.
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