Journal
SCIENTIFIC REPORTS
Volume 9, Issue -, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41598-019-47638-y
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Funding
- European Research Council
- Swedish Research Council
- Knut and Alice Wallenberg foundation
- Marianne and Marcus Wallenberg foundation
- Strategic Research Area MultiPark (Multidisciplinary Research in Parkinson's disease) at Lund University
- Swedish Alzheimer Foundation
- Swedish Brain Foundation
- Parkinson foundation of Sweden
- Parkinson Research Foundation
- Skane University Hospital Foundation
- Swedish federal government under the ALF
- Kockska foundation
- Bundy Academy
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The independent effects of different brain pathologies on age-dependent cognitive decline are unclear. We examined this in 300 cognitively unimpaired elderly individuals from the BioFINDER study. Using cognition as outcome we studied the effects of cerebrospinal fluid biomarkers for amyloid-beta (A beta 42/40), neuroinflammation (YKL-40), and neurodegeneration and tau pathology (T-tau and P-tau) as well as MRI measures of white-matter lesions, hippocampal volume (HV), and regional cortical thickness. We found that A beta positivity and HV were independently associated with memory. Results differed depending on age, with memory being associated with HV (but not A beta) in older participants (73.3-88.4 years), and with A beta (but not HV) in relatively younger participants (65.2-73.2 years). This indicates that A beta and atrophy are independent contributors to memory variability in cognitively healthy elderly and that A beta mainly affects memory in younger elderly individuals. With advancing age, the effect of brain atrophy overshadows the effect of A beta on memory function.
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