Journal
SCIENTIFIC REPORTS
Volume 9, Issue -, Pages -Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41598-019-42937-w
Keywords
-
Categories
Funding
- Austrian Science Foundation [P27166-B23, P28854, I3792]
- Jubilee Foundation of the Austrian National Bank [15858]
- President's International Fellowship Initiative of CAS [2015VBB045]
- National Natural Science Foundation of China [31450110423]
- Austrian Research Promotion Agency [FFG: 864690]
- Integrative Metabolism Research Center Graz
- OMICS Center Graz
- Austrian infrastructure program 2016/2017, BioTechMed/Graz
- Austrian Science Fund (FWF) [P28854, P27166] Funding Source: Austrian Science Fund (FWF)
Ask authors/readers for more resources
Considering the already established relationship between the extent of the metabolic dysfunction and the severity of heart failure (HF), it is conceivable that the metabolomic profile of the serum may have a prognostic capacity for 3-month mortality in acute heart failure (AHF). Out of 152 recruited patients, 130 serum samples were subjected to the metabolomic analyses. The 3-month mortality rate was 24.6% (32 patients). Meta bolomic profiling by nuclear magnetic resonance spectroscopy found that the serum levels of 2-hydroxybutyrate (2-HB), 3-hydoxybutyrate (3-HB), lactate, citrate, and tyrosine, were higher in patients who died within 3 months compared to those who were alive 3 months after onset of AHF, which was confirmed by univariable logistic regression analyses (p = 0.009, p= 0.005, p = 0.008, p<0.001, and p<0.001, respectively). These associations still remained significant for all tested metabolites except for lactate after adjusting for established prognostic parameters in HF. In conclusion, serum levels of 2-HB, 3-HB, tyrosine, and citrate measured at admission are associated with an increased 3-month mortality rate in AHF patients and might thus be of prognostic value in AHF.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available