Journal
SCIENTIFIC REPORTS
Volume 9, Issue -, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41598-019-42100-5
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Funding
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior - Brasil (CAPES) [001]
- CNPq [552148/2011-3, 470716/2013-4]
- CAPES [BEX: 11264/13-6]
- FINEP (CT-Infra)
- FAPESP [2015/23487-8]
- CNPQ-FAPESP [465458/2014-9, 2014/50891]
- USA-Israel Binational Science Foundation (BSF) BSF [2012219]
- National Institutes of Health (NIH)/National Heart Lung and Blood Institute (NHLBI) [1R01-HL098437]
- Office of Naval Research (ONR) [000141010078]
- W. M. Keck Foundation
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Sleep plays a crucial role in the regulation of body homeostasis and rhythmicity in mammals. Recently, a specific component of the sleep structure has been proposed as part of its homeostatic mechanism, named micro-arousal. Here, we studied the unique progression of the dynamic behavior of cortical and hippocampal local field potentials (LFPs) during slow-wave sleep-related to motor-bursts (micro-arousals) in mice. Our main results comprised: (i) an abrupt drop in hippocampal LFP amplitude preceding micro-arousals which persisted until the end of motor-bursts (we defined as t interval, around 4s) and a similar, but delayed amplitude reduction in cortical (S1/M1) LFP activity occurring at micro-arousal onset; (ii) two abrupt frequency jumps in hippocampal LFP activity: from Theta (6-12 Hz) to Delta (2-4 Hz), also t seconds before the micro-arousal onset, and followed by another frequency jump from Delta to Theta range (5-7 Hz), now occurring at micro-arousal onset; (iii) a pattern of cortico-hippocampal frequency communication precedes micro-arousals: the analysis between hippocampal and cortical LFP fluctuations reveal high coherence during tau interval in a broader frequency band (2-12 Hz), while at a lower frequency band (0.5-2 Hz) the coherence reaches its maximum after the onset of micro-arousals. In conclusion, these novel findings indicate that oscillatory dynamics pattern of cortical and hippocampal LFPs preceding micro-arousals could be part of the regulatory processes in sleep architecture.
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