Journal
NPG ASIA MATERIALS
Volume 11, Issue -, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41427-019-0139-5
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Funding
- State Key Laboratory of Military Stomatology [2016KA01]
- National Natural Science Foundation of China [81801848]
- Sichuan Science and Technology Program [2017FZ0046, 2018JZ0026, 2019YJ0554]
- China Postdoctoral Science Foundation [2017M610600]
- Chengdu International Science and Technology Cooperation Foundation [2017-GH02-00025-HZ]
- Hong Kong Scholar Programme
- Australian Research Council
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Due to their inherent hydrophobic and bioinert nature, synthetic degradable polymer-based membranes show inferior stem cell attachment, proliferation, and even differentiation. To overcome these limitations, bioinspired and osteopromotive polydopamine nanoparticle-incorporated fibrous membranes are developed via a two-step route: pH-induced polymerization of dopamine and co-electrospinning of polycaprolactone (PCL) with polydopamine nanoparticles (PDA NPs). Hybrid membranes with optimized PDA NP content exhibit high quantities of apatite deposition and prominent cytocompatibility (cell attachment, spreading and reproduction) and osteo-differentiation potential (alkaline phosphatase activity, calcium mineralization, and osteogenesis-related genes and protein expression) of human mesenchymal stem cells cultured without any growth factors. Importantly, in vivo assessments using a mouse calvarial critical-sized defect demonstrate that the engineered fibrous membranes remarkably boost bone reconstruction and regeneration. Accordingly, our bioinspired PCL-based hybrid fibrous membranes with robust osteoinductive ability can potentially be utilized as a clinically applicable candidate in guided tissue regeneration applications.
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