Journal
MATERIALS
Volume 12, Issue 15, Pages -Publisher
MDPI
DOI: 10.3390/ma12152445
Keywords
polymeric vaccines; respiratory infections; mucosal administration; immunomodulation; nanovaccines
Ask authors/readers for more resources
Communicable respiratory infections are the cause of a significant number of infectious diseases. The introduction of vaccinations has greatly improved this situation. Moreover, adjuvants have allowed for vaccines to be more effective with fewer adverse side effects. However, there is still space for improvement because while the more common injected formulations induce a systematic immunity, they do not confer the mucosal immunity needed for more thorough prevention of the spread of respiratory disease. Intranasal formulations provide systemic and mucosal immune protection, but they have the potential for more serious side effects and a less robust immune response. This review looks at seven different adjuvants-chitosan, starch, alginate, gellan, beta-glucan, emulsan and hyaluronic acid-and their prospective ability to improve intranasal vaccines as adjuvants and antigen delivery systems.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available