Journal
BIOMEDICAL OPTICS EXPRESS
Volume 10, Issue 8, Pages 3963-3973Publisher
OPTICAL SOC AMER
DOI: 10.1364/BOE.10.003963
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Funding
- Canadian Institutes of Health Research (CIHR) [PJT-156110]
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The amount and organization details of peri-tumoural stroma have been linked to patient outcomes in various cancers. In this study, we propose a novel and relatively simple methodology using polarized light microscopy (PLM) to image fibrillar structures within a tumour microenvironment, using only linear crossed polarizers. We demonstrate the technique's ability to image and extract measurement-geometry-independent quantitative morphological metrics related to stromal density and alignment in human invasive breast cancer samples. The findings are promising towards quantitative characterization of peri-tumoural stroma, with potential to develop a PLM signature of tumour microenvironment for providing clinically important information such as breast cancer behaviour or treatment outcome prognosis. (C) 2019 Optical Society of America under the terms of the OSA Open Access Publishing Agreement
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