Journal
BIOMEDICAL OPTICS EXPRESS
Volume 10, Issue 7, Pages 3183-3195Publisher
OPTICAL SOC AMER
DOI: 10.1364/BOE.10.003183
Keywords
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Funding
- National Institutes of Health through SC COBRE [P20RR021949, P20GM130451]
- National Science Foundation EPSCoR Program [OIA-1655740]
- National Natural Science Foundation of China [61775148]
- [R01HL124782]
- [R01HL144927]
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Detecting the structural changes caused by volume and pressure overload is critical to comprehending the mechanisms of physiologic and pathologic hypertrophy. This study explores the structural changes at the crystallographic level in myosin filaments in volume- and pressure-overloaded myocardia through polarization-dependent second harmonic generation microscopy. Here, for the first time, we report that the ratio of nonlinear susceptibility tensor components d(33)/d(15) increased significantly in volume- and pressure-overloaded myocardial tissues compared with the ratio in normal mouse myocardial tissues. Through cell stretch experiments, we demonstrated that mechanical tension plays an important role in the increase of d(33)/d(15) in volume- and pressure-overloaded myocardial tissues. (C) 2019 Optical Society of America under the terms of the OSA Open Access Publishing Agreement
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