Journal
ACS COMBINATORIAL SCIENCE
Volume 21, Issue 8, Pages 573-577Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acscombsci.9b00090
Keywords
carbonylative procedure; benzene-1,3,5-triyl triformate; elemental selenium; heterocycle synthesis
Funding
- NSFC [21772177, 21602201]
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An efficient and general carbonylative procedure for the synthesis of 3,4-dihydroquinazolin-2(1H)-one from 1-(halomethyl)-2-nitrobenzenes and aryl/alkyl amines have been explored. In this approach, to avoid of using toxic CO gas, a solid and stable CO precursor, TFBen (benzene-1,3,5-triyl triformate), was utilized. With elemental selenium as the catalyst, a variety of aryl/alkyl amines has been tolerated well to afford the corresponding 3,4-dihydroquinazolin-2(1H)-one products in moderate to excellent yields under mild reaction condition.
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