Journal
ACS COMBINATORIAL SCIENCE
Volume 21, Issue 7, Pages 548-555Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acscombsci.9b00079
Keywords
triazines; multicomponent reactions; microwave-assisted synthesis; anticancer activity
Ask authors/readers for more resources
A new, effective one-pot synthesis of the 6,N-2-diaryl-1,3,5-triazine-2,4-diamines under microwave irradiation was developed. The method involved an initial three-component condensation of cyanoguanidine, aromatic aldehydes, and arylamines in the presence of hydrochloric acid. Without isolation, the resulting 1,6-diaryl-1,6-dihydro-1,3,5-triazine-2,4-diamines were treated with a base to initiate Dimroth rearrangement and spontaneous dehydrogenative aromatization, affording the desired compounds. The developed method was found to be sufficiently general in scope, tolerating various aromatic aldehydes and amines; by using their combinations in the first step, a representative library of 110 compounds was successfully prepared and screened for anticancer properties.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available