Journal
ACS CATALYSIS
Volume 9, Issue 8, Pages 6751-6754Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acscatal.9b01785
Keywords
nickel; electrochemistry; enantioselective; cross-coupling; asymmetric catalysis
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Funding
- National Science Foundation (Graduate Research Fellowship) [DGE-1144469]
- NIH [R3SGM118191-01]
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An electrochemically driven enantioselective nickel-catalyzed reductive cross-coupling of alkenyl bromides and benzyl chlorides is reported. The reaction forms products bearing allylic stereogenic centers with good enantioselectivity under mild conditions in an undivided cell. Electrochemical activation and turnover of the catalyst mitigate issues posed by metal powder reductants. This report demonstrates that enantioselective Ni-catalyzed cross-electrophile couplings can be driven electrochemically.
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